The Influence of Bordetella Pertussis Vaccination of CFW Mice on Platelet Aggregation and Cyclic Amp Levels in Response to ADP, Aminophylline, Various Biogenic Amines and Prostaglandin E1
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Authors
Klein, Thomas W.
Issue Date
1973
Volume
Issue
Type
Dissertation
Language
en_US
Keywords
Microbiology
Alternative Title
Abstract
The injection of certain strains of mice and rats with living or killed Bordetella pertussis organisms is followed by altered responses of the host to various stimuli including histamine, serotonin, endotoxin, anaphylaxis and cold stress (65, 69). One of these, which has received the attention of a number of investigators, is the marked increase in histamine sensitivity that develops in pertussis-vaccinated hosts. Initially, attempts were made to define the underlying mechanism of this hyperreactive state in terms of either an increased histidine decarboxylase activity (142) or a reduced histaminase activity (66, 83). However, the proposed primary role of these enzyme malfunctions in amine sensitivity was placed in doubt by subsequent evidence (99, 141, 160).
Description
Citation
Publisher
Creighton University
License
A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.