Plasmid-Host Cell Relationships in Staphylococcus Aureus: The Role of Deoxyribonucleic Acid Dark Repair Systems
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Authors
Viola, Colleen Kozisek
Issue Date
1977
Volume
Issue
Type
Thesis
Language
en_US
Keywords
Microbiology
Alternative Title
Abstract
Numerous studies have demonstrated the existence of DNA repair systems which function to preserve the basic integrity of genetic material. These repair systems are of two basic classes: the first class contains a repair system which functions only in the presence of light (photoenzymatic repair); the second class includes those systems which function optimally in the dark (excision and recombinational repair).| Photoenzymatic repair is known to be specific for chromosomal lesions which have been induced by ultraviolet light. In contrast, the dark repair systems are error-correcting mechanisms which alleviate the damaging effects of chromosomal lesions produced by a wide variety of agents, including X-radiation, nitrosoguanidine, and mitomycin C. In addition, it has been reported that mutants deficient in either excision or recombinational repair produce significant numbers of non-viable cells. These observations support the role of DNA dark repair systems in the general maintenance of chromosomal DNA.
Description
Citation
Publisher
Creighton University
License
A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.