Comparative Effects of Various Drugs in Producing Vasodilatation in Peripheral Vascular Conditions

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Authors
Reedy, William Joseph
Issue Date
1950
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Thesis
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en_US
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Abstract
The therapeutic and diagnostic effectiveness of various agents in peripheral vascular conditions has presented a real demand upon investigators and clinicians, It is apparent from the literature that no single pharmacological agent has been uniformly constant in producing the desirable effect of increased blood flow to the extremities. The more difficult aspect of treatment in peripheral vascular disorders relates to the organic occlusive type, particularly the arteriosclerotic type. | Numerous procedures have been used in the treatment of arteriosclerosis obliterans. This paper concerns chiefly some of the pharmacological agents used and prescinds from the surgical or physical measures advocated. Wright (92) in an excellent but limited review advocated encouraging results with oral alcohol. Brown (14) advocated the use of typhoid vaccine. Intravenous typhoid vaccine has given good results in thromboangiitis obliterans but should be used with caution in arteriosclerosis (92), (41). Silbert (80), (81) used intravenous hypertonic saline solution and repeatedly reported successful results. Its use is not without complications. Wright (92) states that it may produce venous thrombosis, chills and hepatitis. He did not recommend this substance in the treatment of arteriosclerosis. Various other intravenous solutions have been suggested (58), sodium citrate by Ginsburg (30) and Steel (85).
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Creighton University
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