A Clinical Investigation of the Use of Promazine Hydrochloride for Pre-Delivery Sedation
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Authors
Langdon, Robert Martin
Issue Date
1960
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Issue
Type
Thesis
Language
en_US
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Abstract
The search for the ideal method of analgesia and sedation during labor and delivery still continues for most obstetricians today, as it has in the past. The last few years have introduced several new drugs, among which are those derived from phenothiazine. Chlorpromazine (Thorazine) has been used and reported extensively. Promethazine has received prominent attention, and for the last several years has been used routinely on the University Service at the Creighton Medical Center. These drugs used in conjunction with meperidine (Demerol) and scopolamine seem to potentiate the effect and give better analgesia and sedation. Chlorpromazine, however, was unpredictable in response and often left much to be desired. Promethazine has received enthusiastic response by our obstetrical staff and has proved safe to mother and infant. | Interest was then focused on promazine hydrochloride. Its molecule structure is the same as chlorpromazine except that promazine lacks the chlorine atom.
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Creighton University
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