Mucoadhesive Nanoparticles for Cancer Treatment
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Authors
Dash, Alekha K.
Trickler, William J.
Issue Date
2012-08-14
Volume
Issue
Type
Patent
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Keywords
Alternative Title
Abstract
The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer therapeutic agent, such as gemcitabine, taxanes, and hydrophobic cancer therapeutic agents). Also disclosed are methods for preparing such nanoparticles and pharmaceutical compositions, as well as methods for treating breast, pancreatic, colon, prostate, and other cancers by parenterally, intravenously, or otherwise administering such nanoparticles and pharmaceutical compositions.
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Publisher
United States Patent Office