Studies on the Beckmann Rearrangement of 3beta-Acetoxycholest-5-En-7-One Oxime: Synthesis Of 3beta-Acetoxy-7a-AZA-B-Homocholest-5-En-7-One
Hahn, Kwang J.
The synthetic modification of naturally occuring steroids has yielded an increasing number of biologically active and therapeutic agents. Modifications of known steroids (androgens, estrogens, progestogens, corticoids, and mineral corticoids) have produced compounds possessing new biological properties, and increased therapeutic value. | Among the modified steroids of interest are the nitrogen-containing azasteroids. The purpose of this investigation was to synthesize one such azasteroid, 3beta-acetoxy-7a-aza-B-homocholest-S-en-7-one via the Beckmann rearrangement of 3beta-acetoxycho-lest-5-en-7-one oxime.
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