Observation of the Inhibitory Effects on Gastric Secretion and Motility by Atropine-Like Agents

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Walsh, Francis A.
Issue Date
1952
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Thesis
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en_US
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Abstract
Pharmacological research has resulted in the development of new anticholinergic drugs. Clinical evaluation of these substances has judged them to be an improvement over older drugs in peptic ulcer management. The most prominent of the older therapeutic agents is atropine. | Using atropine as a standard, this paper will concern itself with an attempt to evaluate the action of newer preparations on both gastric secretion and motility in innervated and denervated pyloric pouch with gastric fistula dogs. | Studies by Benjamin, Roslere and Grossman (1) using Methanthellne bromide and atropine subcutaneously on histamine stimulated gastric pouches showed that both atropine and Methanthellne bromide inhibited gastric secretion. They report atropine to be approximately twenty times stronger than Methanthellne bromide in inhibiting gastric secretion to the same degree (this is based upon concentration of the drug used per kilogram of body weight).
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Creighton University
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